Neolignans inhibit Trypanosoma cruzi infection of its triatomine insect vector, Rhodnius prolixus

@article{Cabral1999NeolignansIT,
  title={Neolignans inhibit Trypanosoma cruzi infection of its triatomine insect vector, Rhodnius prolixus},
  author={Marise Maleck de Oliveira Cabral and Patricia de Azambuja and Otto R. Gottlieb and El{\'o}i de Souza Garcia},
  journal={Parasitology Research},
  year={1999},
  volume={85},
  pages={184-187}
}
Two neolignans, burchellin and nordihydroguaiaretic acid (NDGA), were toxic only to Trypanosoma cruzi clone Dm28c maintained in brain heart infusion (BHI) medium at a concentration of 100 μg/ml, not 10 μg/ml. When Rhodnius prolixus was fed with epimastigotes of T. cruzi and treated simultaneously with a single dose of burchellin or NDGA at 10 μg/ml of blood meal the number of parasites in the gut decreased. Whereas burchellin was only partially active, NDGA drastically reduced the number of… CONTINUE READING