Neointima formation: a local affair.

  title={Neointima formation: a local affair.},
  author={Virginia J Hoglund and Xiu Rong Dong and Mark W. Majesky},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={30 10},
Where do intimal smooth muscle cells (SMCs) come from? For many years, the idea that intimal SMCs originated from the underlying media went unchallenged.1 Then, reports2,3 began to appear that up to half of the SMCs in the intima of atherosclerotic plaques and injured arteries arose from circulating progenitor cells of bone marrow origin. This new view of intimal SMC formation was potentially important because it raised the possibility of a new class of therapeutic targets for intervention in… CONTINUE READING


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