Neogenin and RGMa control neural tube closure and neuroepithelial morphology by regulating cell polarity.

Abstract

In humans, neural tube closure defects occur in 1:1000 pregnancies. The design of new strategies for the prevention of such common defects would benefit from an improved understanding of the molecular events underlying neurulation. Neural fold elevation is a key morphological process that acts during neurulation to drive neural tube closure. However, to… (More)
DOI: 10.1523/JNEUROSCI.4265-08.2008

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