Neocortical pCREB and BDNF expression under different modes of hypobaric hypoxia: role in brain hypoxic tolerance in rats.

@article{Samoilov2014NeocorticalPA,
  title={Neocortical pCREB and BDNF expression under different modes of hypobaric hypoxia: role in brain hypoxic tolerance in rats.},
  author={Michail Olegovich Samoilov and A. V. Churilova and Tatjana S Gluschenko and Elena Rybnikova},
  journal={Acta histochemica},
  year={2014},
  volume={116 5},
  pages={949-57}
}
Preconditioning with repetitive mild hypobaric hypoxia is known to increase tolerance of susceptible brain neurons to severe hypoxia, whereas a single trial of mild hypoxia has been ineffective. In the present study, the effects of three-trial and one-trial hypobaric preconditioning on the expression of the protective transcription factor phosphorylated CREB (pCREB) and neurotrophin BDNF, before and after severe hypobaric hypoxia, have been comparatively studied in the neocortex of rats. As… CONTINUE READING

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