Neocortical lewy body counts correlate with dementia in the Lewy body variant of Alzheimer's disease.

@article{Samuel1996NeocorticalLB,
  title={Neocortical lewy body counts correlate with dementia in the Lewy body variant of Alzheimer's disease.},
  author={W A Samuel and Douglas R. Galasko and Eliezer Masliah and Lawrence Arthur Hansen},
  journal={Journal of neuropathology and experimental neurology},
  year={1996},
  volume={55 1},
  pages={44-52}
}
Patients with the Lewy body variant (LBV) of Alzheimer's disease (AD) meet diagnostic criteria for AD but have a lighter burden of plaque and tangle AD pathology despite comparable dementia. We quantified neocortical Lewy bodies (LB) in LBV patients (n = 14) using anti-ubiquitin polyclonal antibody, selecting for quantification those neocortical regions with the highest densities of LB. Neocortical neurofibrillary tangles (NFT) and neuritic plaques were evaluated with thioflavin- S. A group of… CONTINUE READING

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