Neocortical excitation/inhibition balance in information processing and social dysfunction

@article{Yizhar2011NeocorticalEB,
  title={Neocortical excitation/inhibition balance in information processing and social dysfunction},
  author={Ofer Yizhar and Lief E Fenno and Matthias Prigge and Franziska Schneider and Thomas J Davidson and Daniel J. O’Shea and Vikaas S. Sohal and Inbal Goshen and J. Barnett Finkelstein and Jeanne T Paz and Katja Stehfest and Roman Fudim and Charu Ramakrishnan and John R. Huguenard and Peter Hegemann and Karl Deisseroth},
  journal={Nature},
  year={2011},
  volume={477},
  pages={171-178}
}
Severe behavioural deficits in psychiatric diseases such as autism and schizophrenia have been hypothesized to arise from elevations in the cellular balance of excitation and inhibition (E/I balance) within neural microcircuitry. This hypothesis could unify diverse streams of pathophysiological and genetic evidence, but has not been susceptible to direct testing. Here we design and use several novel optogenetic tools to causally investigate the cellular E/I balance hypothesis in freely moving… CONTINUE READING
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