Neocortical activation: modulation by multiple pathways acting on central cholinergic and serotonergic systems

@article{Dringenberg1997NeocorticalAM,
  title={Neocortical activation: modulation by multiple pathways acting on central cholinergic and serotonergic systems},
  author={Hans C Dringenberg and C. H. Vanderwolf},
  journal={Experimental Brain Research},
  year={1997},
  volume={116},
  pages={160-174}
}
 The present experiments examined the central systems which mediate the electrocorticographic activation induced by electrical stimulation of forebrain and midbrain areas known to play a role in cerebral activation. In urethane-anesthetized rats, 100-Hz electrical stimulation of the amygdaloid cmplex or dorsal raphe changed neocortical electrocorticographic activity from large irregular slow activity (LISA; 1–6 Hz, up to 2 mV) to low voltage fast activity (LVFA; less than 0.5 mV, including… CONTINUE READING

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About 80% of basal forebrain cells that were more active during LISA relative to LVFA were inhibited by single - pulse stimulation of the amygdala or locus coeruleus area .
Single - pulse electrical stimulation of those sites that effectively induced atropine - sensitive LVFA ( amygdala , locus coeruleus area ) produced excitation of over 65% of those extracellularly recorded basal forebrain neurons that fired at higher rates during the presence of neocortical LVFA relative to LISA .
Electrical stimulation of the locus coeruleus area or of the superior colliculus also suppressed LISA and induced LVFA .
The LVFA during stimulation of the locus coeruleus area was abolished by the anti - muscarinic drug atropine ( 50 mg / kg , i.p . ) , whereas the LVFA during superior colliculus stimulation was atropine - resistant but could be abolished by the serotonergic antagonists methiothepin ( 5 mg / kg , i.p . ) or ketanserin ( 5 mg / kg , i.p . ) .
Electrical stimulation of the locus coeruleus area or of the superior colliculus also suppressed LISA and induced LVFA .
The LVFA during stimulation of the locus coeruleus area was abolished by the anti - muscarinic drug atropine ( 50 mg / kg , i.p . ) , whereas the LVFA during superior colliculus stimulation was atropine - resistant but could be abolished by the serotonergic antagonists methiothepin ( 5 mg / kg , i.p . ) or ketanserin ( 5 mg / kg , i.p . ) .
The present experiments examined the central systems which mediate the electrocorticographic activation induced by electrical stimulation of forebrain and midbrain areas known to play a role in cerebral activation .
The present experiments examined the central systems which mediate the electrocorticographic activation induced by electrical stimulation of forebrain and midbrain areas known to play a role in cerebral activation .
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