Neocortex patterning by the secreted signaling molecule FGF8.

@article{FukuchiShimogori2001NeocortexPB,
  title={Neocortex patterning by the secreted signaling molecule FGF8.},
  author={Tomomi Fukuchi-Shimogori and Elizabeth Ann Grove},
  journal={Science},
  year={2001},
  volume={294 5544},
  pages={1071-4}
}
A classic model proposes that the mammalian neocortex is divided into areas early in neurogenesis, but the molecular mechanisms that generate the area map have been elusive. Here we provide evidence that FGF8 regulates development of the map from a source in the anterior telencephalon. Using electroporation-mediated gene transfer in mouse embryos, we show that augmenting the endogenous anterior FGF8 signal shifts area boundaries posteriorly, reducing the signal shifts them anteriorly, and… CONTINUE READING
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