Neocitreamicins I and II, Novel Antibiotics with Activity against Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci

@article{Peoples2008NeocitreamicinsIA,
  title={Neocitreamicins I and II, Novel Antibiotics with Activity against Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci},
  author={Aaron J. Peoples and Qibo Zhang and William P. Millett and Mithra T Rothfeder and Brian C Pescatore and Anne A. Madden and Losee Lucy Ling and Charles M Moore},
  journal={The Journal of Antibiotics},
  year={2008},
  volume={61},
  pages={457-463}
}
Two novel antibiotics, neocitreamicins I and II, were isolated from a fermentation broth of a Nocardia strain. This producing strain was obtained using an in situ diffusion chamber that facilitates the cultivation of soil microorganisms. The structures of neocitreamicins I and II were elucidated using UV, MS, and NMR data, and found to be related to the polycyclic xanthone antibiotics of the citreamicin class. The neocitreamicins showed in vitro activity against Gram-positive bacteria including… 
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TLDR
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Staphylococcus aureus is a most common pathogen in hospital and community acquired disease that causes a wide range of infection such as skin and soft tissue infection to life threatening disease
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Microbial interactions trigger the production of antibiotics.
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