Neobiosynthesis of glycosphingolipids by plasma membrane-associated glycosyltransferases.

  title={Neobiosynthesis of glycosphingolipids by plasma membrane-associated glycosyltransferases.},
  author={Pilar Maria Crespo and Vanina Torres Demichelis and Jos{\'e} Luis Daniotti},
  journal={The Journal of biological chemistry},
  volume={285 38},
Gangliosides, complex glycosphingolipids containing sialic acids, are synthesized in the endoplasmic reticulum and in the Golgi complex. These neobiosynthesized gangliosides move via vesicular transport to the plasma membrane, becoming components of the external leaflet. Gangliosides can undergo endocytosis followed by recycling to the cell surface or sorting to the Golgi complex or lysosomes for remodeling and catabolism. Recently, glycosphingolipid catabolic enzymes (glycohydrolases) have… CONTINUE READING
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