Neoantigen of the polymerized ninth component of complement. Characterization of a monoclonal antibody and immunohistochemical localization in renal disease.

@article{Falk1983NeoantigenOT,
  title={Neoantigen of the polymerized ninth component of complement. Characterization of a monoclonal antibody and immunohistochemical localization in renal disease.},
  author={Ronald J. Falk and Agustin P. Dalmasso and Yeon-sook Kim and Ching Hui Tsai and Jon I. Scheinman and Henry Gewurz and Alfred F. Michael},
  journal={The Journal of clinical investigation},
  year={1983},
  volume={72 2},
  pages={
          560-73
        }
}
A monoclonal antibody to a neoantigen of the C9 portion of the membrane attack complex (MAC) of human complement has been developed and characterized. The distribution of this neoantigen was assessed by indirect immunofluorescence microscopy in nephritic and nonnephritic renal diseases. The antibody (Poly C9-MA) reacted on enzyme-linked immunosorbent assay (ELISA) with a determinant in complement-activated serum that was undetectable in normal human serum (NHS). Zymosan particles incubated in… CONTINUE READING

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