Neoantigen-based cancer immunotherapy.

  title={Neoantigen-based cancer immunotherapy.},
  author={Sara Bobisse and Periklis G. Foukas and George Coukos and Alexandre Harari},
  journal={Annals of translational medicine},
  volume={4 14},
Emerging clinical evidence on the role of the antitumor activity of the immune system has generated great interest in immunotherapy in all cancer types. Recent clinical data clearly demonstrated that human tumor cells express antigenic peptides (epitopes) that can be recognized by autologous tumor-specific T cells and that enhancement of such immune reactivity can potentially lead to cancer control and cancer regression in patients with advanced disease. However, in most cases, it is unclear… CONTINUE READING
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