Neoagarohexaose-mediated activation of dendritic cells via Toll-like receptor 4 leads to stimulation of natural killer cells and enhancement of antitumor immunity

@inproceedings{Lee2017NeoagarohexaosemediatedAO,
  title={Neoagarohexaose-mediated activation of dendritic cells via Toll-like receptor 4 leads to stimulation of natural killer cells and enhancement of antitumor immunity},
  author={Moon Hee Lee and Jong-Hwa Jang and Gun Young Yoon and Seung Jun Lee and Min-Goo Lee and Tae Heung Kang and Hee Dong Han and Hyuk Soon Kim and Wahn Soo Choi and Won Sun Park and Y K Park and In Duk Jung},
  booktitle={BMB reports},
  year={2017}
}
β-Agarase cleaves the β-1,4 linkages of agar to produce neoagarooligosaccharides (NAO), which are associated with various physiological functions. However, the immunological functions of NAO are still unclear. In this study, we demonstrated that β-agarase DagA-produced neoagarohexaose (DP6), an NAO product, promoted the maturation of dendritic cells (DCs) by Toll-like receptor 4 (TLR4). DP6 directly and indirectly enhanced the activation of natural killer (NK) cells in a TLR4-dependent manner… CONTINUE READING

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