Neoadjuvant radiotherapy for locally advanced and high-risk prostate cancer

  title={Neoadjuvant radiotherapy for locally advanced and high-risk prostate cancer},
  author={John Thoms and Jayant Sastri Goda and Alexender R. Zlotta and Neil E. Fleshner and Theodorus H. van der Kwast and St{\'e}phane Supiot and Padraig Richard Warde and Robert G. Bristow},
  journal={Nature Reviews Clinical Oncology},
Men presenting with high-risk or locally advanced prostate cancer may benefit from a combination of radiotherapy and surgery to maximize local control. Adjuvant radiotherapy following surgery has improved biochemical progression-free survival, metastasis-free survival, lengthened the time to hormone therapy use and improved overall survival in three randomized-phase III trials. One surprising result of the Southwest Oncology Group (SWOG) 8794 trial and the European Organisation for Research and… CONTINUE READING
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