Neoadjuvant phase II multicentre study of new agents in patients with malignant glioma after minimal surgery. Report of a cohort of 187 patients treated with temozolomide.

@article{Brada2005NeoadjuvantPI,
  title={Neoadjuvant phase II multicentre study of new agents in patients with malignant glioma after minimal surgery. Report of a cohort of 187 patients treated with temozolomide.},
  author={M M Brada Brada and Susan W. Ashley and Anna Dowe and Arlan de Assis Gonsalves and Aymeri Huchet and Giorgia Pesce and Michele Reni and Frank H. Saran and Beverley Wharram and M. Elaine Wilkins and Peter Wilkins},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2005},
  volume={16 6},
  pages={
          942-9
        }
}
BACKGROUND The aim of this study was to assess the efficacy of new agents in patients with malignant glioma in a neoadjuvant setting not confounded by surgery. The first study of neoadjuvant temozolomide aimed to provide a benchmark for future evaluation of new treatments. PATIENTS AND METHODS This was a multicentre phase II study of chemotherapy in patients with histologically verified glioblastoma multiforme (GBM) and anaplastic astrocytoma (AA) who had undergone biopsy alone. Patients were… CONTINUE READING
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