Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups.

@article{Ferrari2005NeoadjuvantCW,
  title={Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups.},
  author={Stefano Ferrari and Sigbjorn Smeland and Mario Mercuri and Franco Bertoni and Alessandra Longhi and Pietro Ruggieri and Thor Andreas Alvegard and Piero Picci and Riccardo Capanna and Gabriella Bernini and Cristoph M{\"u}ller and Amelia Tienghi and Thomas Wiebe and Alessandro Comandone and Tom B{\"o}hling and A b Del prever and Otte Brosjoe and Gaetano Bacci and Gunnar Saeter},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2005},
  volume={23 34},
  pages={
          8845-52
        }
}
PURPOSE To explore the effect of high-dose ifosfamide in first-line treatment for patients < or = 40 years of age with nonmetastatic osteosarcoma of the extremity. PATIENTS AND METHODS From March 1997 to September 2000, 182 patients were evaluated. Primary treatment consisted of two blocks of high-dose ifosfamide (15 g/m2), methotrexate (12 g/m2), cisplatin (120 mg/m2), and doxorubicin (75 mg/m2). Postoperatively, patients received two cycles of doxorubicin (90 mg/m2), and three cycles each… CONTINUE READING
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