Neoadjuvant chemotherapy prior to preoperative chemoradiation or radiation in rectal cancer: should we be more cautious?

@article{GlynneJones2006NeoadjuvantCP,
  title={Neoadjuvant chemotherapy prior to preoperative chemoradiation or radiation in rectal cancer: should we be more cautious?},
  author={Robert Glynne-Jones and Juliet Grainger and Mark S. Harrison and Peter J. Ostler and Andreas Makris},
  journal={British Journal of Cancer},
  year={2006},
  volume={94},
  pages={363 - 371}
}
Neoadjuvant chemotherapy (NACT) is a term originally used to describe the administration of chemotherapy preoperatively before surgery. The original rationale for administering NACT or so-called induction chemotherapy to shrink or downstage a locally advanced tumour, and thereby facilitate more effective local treatment with surgery or radiotherapy, has been extended with the introduction of more effective combinations of chemotherapy to include reducing the risks of metastatic disease. It… CONTINUE READING