Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer.

@article{Vergote2010NeoadjuvantCO,
  title={Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer.},
  author={Ignace Vergote and Claes G{\"o}ran Trop{\'e} and Fr{\'e}d{\'e}ric Amant and Gunnar Balle Kristensen and Tom Ehlen and Nick Johnson and Ren{\'e} H. M. Verheijen and Maria E. L. van der Burg and Angel Jim{\'e}nez Lacave and Pierluigi Benedetti Panici and Gemma G Kenter and Antonio Cuevas Casado and C{\'e}sar Mendiola and Corneel Coens and L Verleye and Gavin C. E. Stuart and Sergio Pecorelli and Nick Simon Reed},
  journal={The New England journal of medicine},
  year={2010},
  volume={363 10},
  pages={943-53}
}
BACKGROUND Primary debulking surgery before initiation of chemotherapy has been the standard of care for patients with advanced ovarian cancer. METHODS We randomly assigned patients with stage IIIC or IV epithelial ovarian carcinoma, fallopian-tube carcinoma, or primary peritoneal carcinoma to primary debulking surgery followed by platinum-based chemotherapy or to neoadjuvant platinum-based chemotherapy followed by debulking surgery (so-called interval debulking surgery). RESULTS Of the 670… CONTINUE READING
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