Neoadjuvant chemoradiotherapy with or without panitumumab in patients with wild-type KRAS, locally advanced rectal cancer (LARC): a randomized, multicenter, phase II trial SAKK 41/07.

@article{Helbling2013NeoadjuvantCW,
  title={Neoadjuvant chemoradiotherapy with or without panitumumab in patients with wild-type KRAS, locally advanced rectal cancer (LARC): a randomized, multicenter, phase II trial SAKK 41/07.},
  author={Daniel Helbling and Gyorgy Bodoky and Oliver Gautschi and H Sun and Fred Bosman and Bonnie Gloor and Ren{\'e} Burkhard and Ralph Winterhalder and Axel Madlung and Daniela Rauch and Piercarlo Saletti and Lamarr Widmer and Markus M. Borner and Daniela Baertschi and Ping Yan and Jean Benhattar and Elisabeth Oppliger Leibundgut and St{\'e}phanie Bougel and Dieter Koeberle},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2013},
  volume={24 3},
  pages={718-25}
}
BACKGROUND We conducted a randomized, phase II, multicenter study to evaluate the anti-epidermal growth factor receptor (EGFR) mAb panitumumab (P) in combination with chemoradiotherapy (CRT) with standard-dose capecitabine as neoadjuvant treatment for wild-type KRAS locally advanced rectal cancer (LARC). PATIENTS AND METHODS Patients with wild-type KRAS, T3-4 and/or N+ LARC were randomly assigned to receive CRT with or without P (6 mg/kg). The primary end-point was pathological near-complete… CONTINUE READING
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