Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKKβ.

Shang-ze Li, Hui-hui Zhang, +6 authors Xiao-dong Zhang
Published 2014 in Biochimica et biophysica acta

Abstract

Stringent negative regulation of the transcription factor NF-κB is essential for maintaining cellular stress responses and homeostasis. However, the tight regulation mechanisms of IKKβ are still not clear. Here, we reported that nemo-like kinase (NLK) is a suppressor of tumor necrosis factor (TNFα)-induced NF-κB signaling by inhibiting the phosphorylation… (More)

DOI: 10.1016/j.bbamcr.2014.03.028

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6 Figures and Tables

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References

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Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKKβ.

Abstract

Topics

6 Figures and Tables

Cited By

c-Kit modifies the inflammatory status of smooth muscle cells

Nemo-like kinase as a negative regulator of nuclear receptor Nurr1 gene transcription in prostate cancer

Psoriasis-Specific RNA Isoforms Identified by RNA-Seq Analysis of 173,446 Transcripts

Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology

Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates the interleukin-1β-stimulated C/EBP signaling pathway.

References

The IKK complex

The IκB kinase complex in NF-κB regulation and beyond.

Ubiquitination in signaling to and activation of IKK.

Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NFκB2 signaling that contributes to autoimmunity.

Homodimerization of Nemo-like kinase is essential for activation and nuclear localization

NF-kappaB

The role of TRADD in TRAIL-induced apoptosis and signaling.

The nuclear signaling of NF-κB: current knowledge, new insights, and future perspectives

Epitope tagging of endogenous proteins for genome-wide ChIP-chip studies

Shared Principles in NF-κB Signaling

Slides referencing similar topics

Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKKβ.

Abstract

Topics

6 Figures and Tables

Cited By

c-Kit modifies the inflammatory status of smooth muscle cells

Nemo-like kinase as a negative regulator of nuclear receptor Nurr1 gene transcription in prostate cancer

Psoriasis-Specific RNA Isoforms Identified by RNA-Seq Analysis of 173,446 Transcripts

Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology

Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates the interleukin-1β-stimulated C/EBP signaling pathway.

References

The IKK complex

The IκB kinase complex in NF-κB regulation and beyond.

Ubiquitination in signaling to and activation of IKK.

Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NFκB2 signaling that contributes to autoimmunity.

Homodimerization of Nemo-like kinase is essential for activation and nuclear localization

NF-kappaB

The role of TRADD in TRAIL-induced apoptosis and signaling.

The nuclear signaling of NF-κB: current knowledge, new insights, and future perspectives

Epitope tagging of endogenous proteins for genome-wide ChIP-chip studies

Shared Principles in NF-κB Signaling

Similar Papers

Slides referencing similar topics