Whole animal modeling: piecing together nematode locomotion
- BiologyCurrent Opinion in Systems Biology
An Integrated Neuromechanical Model of Steering in C. elegans
Analysis of the sensorimotor transformation and phasic stimulation experiments provides evidence that the principles of operation for steering discussed in the model are relevant for steering in the worm.
From head to tail: a neuromechanical model of forward locomotion in Caenorhabditis elegans
- BiologyPhilosophical Transactions of the Royal Society B: Biological Sciences
Analysis of the development and analysis of a model of forward locomotion that integrates the neuroanatomy, neurophysiology and body mechanics of the worm revealed that head motoneurons SMD and RMD are sufficient to drive dorsoventral undulations in the head and neck and that short-range posteriorly directed proprioceptive feedback is sufficient to propagate the wave along the rest of the body.
Intrinsic and Extrinsic Modulation of C. elegans Locomotion
- Biology, PsychologybioRxiv
An integrated neuromechanical computational model is used to study the combined effects of neural modulation, mechanical modulation and modulation of the external environments on undulatory forward locomotion in the nematode C. elegans.
The whole worm: brain–body–environment models of C. elegans
- BiologyCurrent Opinion in Neurobiology
A neuromechanical model of multiple network oscillators for forward locomotion in C. elegans
A simulation model is used to demonstrate that a repeating neural circuit identified in the worm’s connectome can be chained together to drive forward locomotion on agar in a neuromechanical model of the nematode, in the absence of pacemaker neurons or stretch-receptor feedback.
From head to tail: A neuromechanical model of forward locomotion in C. elegans
Analysis of the development and analysis of a model of forward locomotion that integrates the neuroanatomy, neurophysiology and body mechanics of the worm revealed that head motoneurons SMD and RMD are sufficient to drive dorsoventral undulations in the head and neck and that short-range posteriorly-directed proprioceptive feedback is sufficient to propagate the wave along the rest of the body.
Functionally asymmetric motor neurons coordinate locomotion of Caenorhabditis elegans
AS MNs have essential roles in coordinating locomotion, combining several functions, and emphasizing the compressed nature of the C. elegans nervous system in comparison to higher animals.
Signatures of proprioceptive control in C. elegans locomotion
- Biology, Psychology
A computational model is used to identify effects of neural and mechanical modulation on undulatory forward locomotion of C. elegans, with a focus on proprioceptively driven neural control, and reveals a fundamental relationship between body elasticity and environmental drag in determining the dynamics of the body.
Propagation of rhythmic dorsoventral wave in a neuromechanical model of locomotion in Caernohabditis elegans
- Biology, Engineering
This work reports on the evolution and analysis of an integrated neuromechanical model of forward locomotion in Caernohabditis elegans and its applications in medicine and neuroscience.
SHOWING 1-10 OF 78 REFERENCES
Gait Modulation in C. elegans: An Integrated Neuromechanical Model
- BiologyFront. Comput. Neurosci.
A model of C. elegans forward locomotion is presented that includes a neuromuscular control system that relies on a sensory feedback mechanism to generate undulations and is integrated with a physical model of the body and environment and reproduces the entire swim-crawl transition with no modulatory mechanism.
Neural control of Caenorhabditis elegans forward locomotion: the role of sensory feedback
- BiologyBiological Cybernetics
A simple yet biologically-grounded model for the neural control of Caenorhabditis elegans forward locomotion finds that a minimal circuit of AVB interneurons and B-class motoneurons is sufficient to generate and sustain fictiveforward locomotion patterns that are robust to significant environmental perturbations.
Systems level circuit model of C. elegans undulatory locomotion: mathematical modeling and molecular genetics
- BiologyJournal of Computational Neuroscience
The model reveals that stretch receptor coupling in the body wall is critical for generation of the neuromuscular wave, and agrees with behavioral data and with other pertinent published data, e.g., that frequency is an increasing function of muscle gap-junction coupling.
The computational worm: spatial orientation and its neuronal basis in C. elegans
- Biology, PsychologyCurrent Opinion in Neurobiology
Evolution and Analysis of Minimal Neural Circuits for Klinotaxis in Caenorhabditis elegans
- BiologyThe Journal of Neuroscience
A minimalistic neural network, comprised of an ON-OFF pair of chemosensory neurons and a pair of neck muscle motor neurons, is sufficient to generate realistic klinotaxis behavior, suggesting that the model may be operating according to principles similar to those of the biological network.
Forward locomotion of the nematode C. elegans is achieved through modulation of a single gait
- Biology, EngineeringHFSP journal
A smooth transition from swimming to crawling is revealed, marked by a linear relationship between key locomotion metrics, and it is shown that environmental forces play only a small role in determining the shape of the worm, placing conditions on the minimal pattern of internal forces driving locomotion.
Theory of the locomotion of nematodes: control of the somatic motor neurons by interneurons.
- BiologyMathematical biosciences
Adaptive Undulatory Locomotion of a C. elegans Inspired Robot
- EngineeringIEEE/ASME Transactions on Mechatronics
Although significant progress has been made in the development of robots with serpentine properties, the issues of motion control and adaptation to environmental constraints still require substantial…
An Image-Free Opto-Mechanical System for Creating Virtual Environments and Imaging Neuronal Activity in Freely Moving Caenorhabditis elegans
- BiologyPloS one
A system that tracks neuron-sized fluorescent targets in real time is devised that can be used to create virtual environments by optogenetic activation of sensory neurons, or to image activity in identified neurons at high magnification, and test the long-standing hypothesis that forward and reverse locomotion are generated by distinct neuronal circuits.
Neuronal microcircuits for decision making in C. elegans
- BiologyCurrent Opinion in Neurobiology