Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy.

@article{Pore2006NelfinavirDH,
  title={Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy.},
  author={Nabendu Pore and Anjali K. Gupta and George J. Cerniglia and Zibin Jiang and Eric J. Bernhard and Sydney M Evans and Cameron J. Koch and Stephen M. Hahn and Amit M Maity},
  journal={Cancer research},
  year={2006},
  volume={66 18},
  pages={9252-9}
}
The phosphatidylinositol 3-kinase (PI3K)/Akt pathway can increase vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1alpha (HIF-1alpha) expression. We examined the effect of nelfinavir, an HIV protease inhibitor that inhibits Akt signaling, on VEGF and HIF-1alpha expression and on angiogenesis, tumor oxygenation, and radiosensitization. Nelfinavir decreases VEGF expression under normoxia via the transcription factor Sp1, which regulates the proximal core VEGF promoter… CONTINUE READING

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