Nelfinavir and bortezomib inhibit mTOR activity via ATF4-mediated sestrin-2 regulation.

@article{Bruening2013NelfinavirAB,
  title={Nelfinavir and bortezomib inhibit mTOR activity via ATF4-mediated sestrin-2 regulation.},
  author={A. M. Bruening and Martina Rahmeh and Klaus Friese},
  journal={Molecular oncology},
  year={2013},
  volume={7 6},
  pages={1012-8}
}
Endoplasmic reticulum (ER) stress and autophagy are two basic cell survival mechanisms often occurring in concert. Extensive ER stress in cancer cells deliberately induced by chemotherapeutic drugs may lead to growth arrest and cell death. However, the link between ER stress and autophagy is not well understood. In this study, the treatment of cancer cells with ER stress-inducing drug nelfinavir resulted in the expression of endogenous mTOR inhibitor sestrin-2 (SESN2). Upregulation of SESN2… CONTINUE READING