Nelfinavir/ritonavir reduces acinar injury but not inflammation during mouse caerulein pancreatitis.


There is no clinical treatment that reduces acinar injury during pancreatitis. Human immunodeficiency virus (HIV) protease inhibitors (PI), including nelfinavir (NFV) and ritonavir (RTV), may reduce the rate of pancreatitis in HIV-infected patients. Since permeability transition pore (PTPC)-mediated mitochondrial dysfunction occurs during pancreatitis, and… (More)
DOI: 10.1152/ajpgi.90642.2008


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