Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy

@article{Salem2010Nek7KT,
  title={Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy},
  author={Hagit Salem and Inbal Rachmin and Nissan Yissachar and Sarah S. Cohen and Aldine Amiel and Rebecca Haffner and L Lavi and Benny Motro},
  journal={Oncogene},
  year={2010},
  volume={29},
  pages={4046-4057}
}
The mammalian NIMA-related kinases (Neks) are commonly referred to as mitotic kinases, although a definitive in vivo verification of this definition is largely missing. Reduction in the activity of Nek7 or its close paralog, Nek6, has previously been shown to arrest cells in mitosis, mainly at metaphase. In this study, we investigate the developmental and cellular roles of Nek7 kinase through the generation and analysis of Nek7-deficient mice. We show that absence of Nek7 leads to lethality in… CONTINUE READING

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