Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1.

@article{Tan2017Nek7PT,
  title={Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1.},
  author={Rong Tan and Satoshi Nakajima and Qun Wang and Hongxiang Sun and Jing Xue and Jian Wu and Sabine Hellwig and Xuemei Zeng and Nathan A. Yates and Thomas E Smithgall and Ming Lei and Yu Jiang and Arthur Samuel Levine and Bing Su and Li Lan},
  journal={Molecular cell},
  year={2017},
  volume={65 5},
  pages={818-831.e5}
}
Telomeric repeat binding factor 1 (TRF1) is essential to the maintenance of telomere chromatin structure and integrity. However, how telomere integrity is maintained, especially in response to damage, remains poorly understood. Here, we identify Nek7, a member of the Never in Mitosis Gene A (NIMA) kinase family, as a regulator of telomere integrity. Nek7 is… CONTINUE READING