Neither sequence variation in the IL-10 gene promoter nor presence of IL-10 protein in the cerebral cortex is associated with Alzheimer's disease.

@article{Culpan2006NeitherSV,
  title={Neither sequence variation in the IL-10 gene promoter nor presence of IL-10 protein in the cerebral cortex is associated with Alzheimer's disease.},
  author={Doris Culpan and Jonathan A. Prince and Sonia Matthews and Laura Palmer and Anthony Hughes and Seth Love and Patrick Gavin Kehoe and G. K. Wilcock},
  journal={Neuroscience letters},
  year={2006},
  volume={408 2},
  pages={141-5}
}
Interleukin 10 (IL-10) is an important anti-inflammatory cytokine produced in response to neuroinflammation and might be involved in modulating the progression of Alzheimer's disease (AD) through inhibiting the action of pro-inflammatory cytokines. We have used immunohistochemistry, Western blotting, real time-PCR (RT-PCR) on frontal (BA 6/24) and temporal (BA 20-22) neocortex and hippocampus from AD and control brains as well as genetic association analysis to address the possible involvement… CONTINUE READING