Neither cyclic AMP nor cyclic GMP appear to mediate antral gastrin release in the dog.

To evaluate whether cyclic nucleotides play a role as mediators in antral gastrin release, the following in vivo experiments were performed in dogs. An antral pouch was constructed and the rest of the stomach, the pancreas and small and large intestine were resected. A gastric artery supplying the pouch was cannulated, and after a basal period with saline… (More)