Neither IL-1beta, IL-1 receptor antagonist, nor TNF-alpha polymorphisms are associated with susceptibility to COPD.

@article{Ishii2000NeitherII,
  title={Neither IL-1beta, IL-1 receptor antagonist, nor TNF-alpha polymorphisms are associated with susceptibility to COPD.},
  author={Tomohiro Ishii and Takeshi Matsuse and Shinji Teramoto and Hirotoshi Matsui and Mariko Miyao and Takayuki Hosoi and Hiroki Takahashi and Yoshinosuke Fukuchi and Yasuyoshi Ouchi},
  journal={Respiratory medicine},
  year={2000},
  volume={94 9},
  pages={847-51}
}
The cytokines that contribute to airway inflammation, including interleukin-1beta (IL-1beta) and tumour necrosis factor alpha (TNFalpha), might have key roles in the development of chronic obstructive pulmonary disease (COPD). Interleukin-1 receptor antagonist (IL-1RN), the physiological antagonist of IL-1beta, is also known to play a crucial role in several chronic inflammatory diseases. In this study, we investigated the association of the polymorphisms of IL-1beta, IL-1RN and TNFalpha with… CONTINUE READING

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