Neisserial outer membrane vesicles bind the coinhibitory receptor carcinoembryonic antigen-related cellular adhesion molecule 1 and suppress CD4+ T lymphocyte function.

@article{Lee2007NeisserialOM,
  title={Neisserial outer membrane vesicles bind the coinhibitory receptor carcinoembryonic antigen-related cellular adhesion molecule 1 and suppress CD4+ T lymphocyte function.},
  author={Hannah W. Lee and Ian C. Boulton and Karen M. Reddin and Henry Hei Wong and Denise Halliwell and Ofer Mandelboim and Andrew R. Gorringe and Scott D Gray-Owen},
  journal={Infection and immunity},
  year={2007},
  volume={75 9},
  pages={4449-55}
}
Pathogenic Neisseria bacteria naturally liberate outer membrane "blebs," which are presumed to contribute to pathology, and the detergent-extracted outer membrane vesicles (OMVs) from Neisseria meningitidis are currently employed as meningococcal vaccines in humans. While the composition of these vesicles reflects the bacteria from which they are derived, the functions of many of their constituent proteins remain unexplored. The neisserial colony opacity-associated Opa proteins function as… CONTINUE READING