Neisserial immunoglobulin A1 protease induces specific T-cell responses in humans.

@article{Tsirpouchtsidis2002NeisserialIA,
  title={Neisserial immunoglobulin A1 protease induces specific T-cell responses in humans.},
  author={Anastasios Tsirpouchtsidis and Robert Hurwitz and V Brinkmann and Thomas F. Meyer and Gaby Haas},
  journal={Infection and immunity},
  year={2002},
  volume={70 1},
  pages={335-44}
}
We have previously shown that immunoglobulin A1 (IgA1) protease, an exoenzyme of pathogenic neisseriae, can trigger the release of proinflammatory cytokines from human monocytic subpopulations. Here, we demonstrate a dose-dependent T-cell response to recombinant gonococcal IgA1 protease (strain MS11) in healthy human blood donors. This response was delayed in comparison to the immune response against tetanus toxoid. Stimulation with IgA1 protease led to the activation of CD4(+) and CD8(+) T… CONTINUE READING