Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates

  title={Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates},
  author={Muriel C. Schneider and Beverly E. Prosser and Joseph J. E. Caesar and Elisabeth Kugelberg and Su Zhi Li and Qian Zhang and Sadik Quoraishi and Janet E Lovett and Janet E Deane and Robert B Sim and Pietro Roversi and Steven Johnson and Christoph M Tang and Susan M Lea},
The complement system is an essential component of the innate and acquired immune system, and consists of a series of proteolytic cascades that are initiated by the presence of microorganisms. In health, activation of complement is precisely controlled through membrane-bound and soluble plasma-regulatory proteins including complement factor H (fH; ref. 2), a 155 kDa protein composed of 20 domains (termed complement control protein repeats). Many pathogens have evolved the ability to avoid… CONTINUE READING
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Structural basis for complement factor H linked age-related macular degeneration

  • BE Prosser
  • J Exp Med
  • 2007

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