Neisseria meningitidis factor H-binding protein fHbp: a key virulence factor and vaccine antigen.

@article{Seib2015NeisseriaMF,
  title={Neisseria meningitidis factor H-binding protein fHbp: a key virulence factor and vaccine antigen.},
  author={Kate L Seib and Maria Scarselli and Maurizio Comanducci and Daniela Toneatto and Vega Masignani},
  journal={Expert review of vaccines},
  year={2015},
  volume={14 6},
  pages={841-59}
}
Neisseria meningitidis is a leading cause of meningitis and sepsis worldwide. The first broad-spectrum multicomponent vaccine against serogroup B meningococcus (MenB), 4CMenB (Bexsero(®)), was approved by the EMA in 2013, for prevention of MenB disease in all age groups, and by the US FDA in January 2015 for use in adolescents. A second protein-based MenB vaccine has also been approved in the USA for adolescents (rLP2086, Trumenba(®)). Both vaccines contain the lipoprotein factor H-binding… CONTINUE READING
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