Neisseria gonorrhoeae delays the onset of apoptosis in polymorphonuclear leukocytes

@article{Simons2006NeisseriaGD,
  title={Neisseria gonorrhoeae delays the onset of apoptosis in polymorphonuclear leukocytes},
  author={Mark P. Simons and William M Nauseef and Thomas S. Griffith and Michael A. Apicella},
  journal={Cellular Microbiology},
  year={2006},
  volume={8}
}
Neisseria gonorrhoeae (gonococcus) infection results in recruitment of polymorphonuclear leukocytes (PMNs) to the urethral lumen. Recent work from our laboratory demonstrated that N. gonorrhoeae resists killing and replicates within PMNs. In this study, we examined the effect of gonococci on PMN viability. Using both transmission electron microscopy and light microscopy, we observed nuclear condensation after 6 h in PMNs that were resting or challenged with opsonized zymosan particles (OPZ). In… Expand
Neisseria gonorrhoeae-Mediated Inhibition of Apoptotic Signalling in Polymorphonuclear Leukocytes
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An HL-60 myeloid leukemia cell culture model for PMN infection is developed and validated and it is shown that N. gonorrhoeae infection alone does not induce apoptosis, but actively inhibits apoptosis induced by multiple stimuli to prolong PMN survival and potentially facilitate bacterial survival, replication, and transmission. Expand
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TLDR
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Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis
TLDR
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