Neisseria gonorrhoeae PilV, a type IV pilus-associated protein essential to human epithelial cell adherence.

@article{WintherLarsen2001NeisseriaGP,
  title={Neisseria gonorrhoeae PilV, a type IV pilus-associated protein essential to human epithelial cell adherence.},
  author={Hanne Cecilie Winther-Larsen and Finn Terje Hegge and Matthew C Wolfgang and Stanley F. Hayes and Jos P M van Putten and Michael Koomey},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 26},
  pages={15276-81}
}
Type IV pili (Tfp) of Neisseria gonorrhoeae, the Gram-negative etiologic agent of gonorrhea, facilitate colonization of the human host. Tfp are assumed to play a key role in the initial adherence to human epithelial cells by virtue of the associated adhesin protein PilC. To examine the structural and functional basis for adherence in more detail, we identified potential genes encoding polypeptides sharing structural similarities to PilE (the Tfp subunit) within the N. gonorrhoeae genome… CONTINUE READING
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