Neisseria gonorrhoeae DNA recombination and repair enzymes protect against oxidative damage caused by hydrogen peroxide.

@article{Stohl2006NeisseriaGD,
  title={Neisseria gonorrhoeae DNA recombination and repair enzymes protect against oxidative damage caused by hydrogen peroxide.},
  author={Elizabeth A. Stohl and H Steven Seifert},
  journal={Journal of bacteriology},
  year={2006},
  volume={188 21},
  pages={7645-51}
}
The strict human pathogen Neisseria gonorrhoeae is exposed to oxidative damage during infection. N. gonorrhoeae has many defenses that have been demonstrated to counteract oxidative damage. However, recN is the only DNA repair and recombination gene upregulated in response to hydrogen peroxide (H(2)O(2)) by microarray analysis and subsequently shown to be important for oxidative damage protection. We therefore tested the importance of RecA and DNA recombination and repair enzymes in conferring… CONTINUE READING

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DNA RepairProcess involves geneRAD51 gene
We propose that RecA , recombinational DNA repair , and branch migration are all important for H(2)O(2 ) resistance in N. gonorrhoeae but that constitutive levels of these enzymes are sufficient for providing protection against oxidative damage by H(2)O(2 ) .
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