Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice

@inproceedings{Mllersen2012Neil1IA,
  title={Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice},
  author={Linda M\ollersen and Alexander D L Rowe and Jennifer L. Illuzzi and Gunn Annette Hildrestrand and Katharina J. Gerhold and Linda Tveter{\aa}s and Anja Bj\olgerud and David M Wilson and Magnar Bj\or{\aa}s and Arne Klungland},
  booktitle={Human molecular genetics},
  year={2012}
}
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by trinucleotide repeat (TNR) expansions. We show here that somatic TNR expansions are significantly reduced in several organs of R6/1 mice lacking exon 2 of Nei-like 1 (Neil1) (R6/1/Neil1(-/-)), when compared with R6/1/Neil1(+/+) mice. Somatic TNR expansion is measured by two different methods, namely mean repeat change and instability index. Reduced somatic expansions are more pronounced in male R6/1/Neil1(-/-) mice… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Structure-dependent DNA damage and repair in a trinucleotide repeat

D. A. Jarem, N. R. Wilson, S. Delaney
sequence. Biochemistry, • 2009

Similar Papers

Loading similar papers…