Neighboring cysteine residues in human fucosyltransferase VII are engaged in disulfide bridges, forming small loop structures.

Abstract

Among alpha 3-fucosyltransferases (alpha3-FucTs) from most species, four cysteine residues appear to be highly conserved. Two of these cysteines are located at the N-terminus and two at the C-terminus of the catalytic domain. FucT VII possesses two additional cysteines in close proximity to each other located in the middle of the catalytic domain. We… (More)

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