Negligible particle-specific toxicity mechanism of silver nanoparticles: the role of Ag+ ion release in the cytosol.

@article{Matteis2015NegligiblePT,
  title={Negligible particle-specific toxicity mechanism of silver nanoparticles: the role of Ag+ ion release in the cytosol.},
  author={Valeria de Matteis and Maria Ada Malvindi and Antonio Galeone and Virgilio Brunetti and Elisa De Luca and Sachin Sayaji Kote and Prakash Kshirsagar and Stefania Sabella and Giuseppe Bardi and Pier Paolo Pompa},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  year={2015},
  volume={11 3},
  pages={731-9}
}
Toxicity of silver nanoparticles (AgNPs) is supported by many observations in literature, but no mechanism details have been proved yet. Here we confirm and quantify the toxic potential of fully characterized AgNPs in HeLa and A549 cells. Notably, through a specific fluorescent probe, we demonstrate the intracellular release of Ag(+) ions in living cells after nanoparticle internalization, showing that in-situ particle degradation is promoted by the acidic lysosomal environment. The activation… CONTINUE READING
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Sizedependent cytotoxicity of silver nanoparticles in human lung cells: the role of cellular uptake, agglomeration and Ag release

  • AR Gliga, S Skoglund, IO Wallinder, B Fadeel, HL. Karlsson
  • Part Fibre Toxicol 2014;11:11
  • 2014

The dissolution and biological effects of silver nanoparticles in biological media

  • K Loza, J Diendorf, +5 authors M. Epple
  • J Mater Chem B
  • 2014

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