Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells
@article{Araki2013NegligibleIO, title={Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells}, author={Ryoko Araki and M. Uda and Yuko Hoki and Misato Sunayama and Miki Nakamura and Shunsuke Ando and Mayumi Sugiura and Hisashi Ideno and Akemi Shimada and Akira Nifuji and Masumi Abe}, journal={Nature}, year={2013}, volume={494}, pages={100-104} }
The advantages of using induced pluripotent stem cells (iPSCs) instead of embryonic stem (ES) cells in regenerative medicine centre around circumventing concerns about the ethics of using ES cells and the likelihood of immune rejection of ES-cell-derived tissues. However, partial reprogramming and genetic instabilities in iPSCs could elicit immune responses in transplant recipients even when iPSC-derived differentiated cells are transplanted. iPSCs are first differentiated into specific types…
472 Citations
The immunogenicity of cells derived from induced pluripotent stem cells
- BiologyCellular and Molecular Immunology
- 2014
A recent breakthrough in the technology of induced pluripotent stem cells (iPSCs) by nuclear reprogramming of patient-specific somatic cells with defined factors could become a renewable source of autologous cells for cell therapy.
Low immunogenicity of mouse induced pluripotent stem cell-derived neural stem/progenitor cells
- Biology, MedicineScientific Reports
- 2017
The immunogenicity and post-transplantation immunological dynamics of iPSC-NSPCs resemble those of fetus-N SPCs.
The Immunogenicity and Immune Tolerance of Pluripotent Stem Cell Derivatives
- Biology, MedicineFront. Immunol.
- 2017
The mechanism underlying the immunogenicity of the pluripotent stem cells and recent progress in developing immune tolerance strategies of human pluripoline stem cell (hPSC)-derived allografts are discussed.
pluripotent stem cells Potentially immunogenic proteins expressed similarly in human embryonic stem cells and induced
- Biology
- 2014
Whether the human homologs of these markers, HORMAD1, ZG16, and Cyp3A, are differentially expressed in human iPS versus ES cells, as well as undifferentiated and in vitro-differentiated cells is examined.
Potentially immunogenic proteins expressed similarly in human embryonic stem cells and induced pluripotent stem cells
- BiologyExperimental biology and medicine
- 2014
Whether the human homologs of these markers, HORMAD1, ZG16, and Cyp3A, are differentially expressed in human iPS versus ES cells, as well as undifferentiated and in vitro-differentiated cells is examined.
Immune tolerance of human induced pluripotent stem cell-derived myogenic progenitor cells in humanized mice
- BiologybioRxiv
- 2019
The results showed that while allogeneic grafts were rejected and highly infiltrated with human T cells, engraftment of autologous cells was tolerated, indicating reprogramming and differentiation procedures are not immunogenic.
Low Immunogenicity of Neural Progenitor Cells Differentiated from Induced Pluripotent Stem Cells Derived from Less Immunogenic Somatic Cells
- BiologyPloS one
- 2013
The groundbreaking discovery of induced pluripotent stem cells (iPS cells) provides a new source for cell therapy. However, whether the iPS derived functional lineages from different cell origins…
Immunogenicity and tumorigenicity of human pluripotent stem cells
- Biology, Medicine
- 2014
iPSC- derived cells could be immunogenic in syngeneic recipients but immune tolerated due to immune suppressive microenvironment, and significant progress has been made to establish novel strategies to induce immune tolerance of allogeneic hESC-derived allografts.
Modulation of human allogeneic and syngeneic pluripotent stem cells and immunological implications for transplantation.
- Biology, MedicineTransplantation reviews
- 2016
New Immunosuppressive Cell Therapy to Prolong Survival of Induced Pluripotent Stem Cell–Derived Allografts
- Medicine, BiologyTransplantation
- 2015
A certain fraction of macrophage-like cells with immunosuppressive functions can be generated from donor iPSCs, which contribute to the prolonged survival of grafts derived from the same iPSC resource in allogeneic recipients.
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