• DOI:10.1038/nature11807
Corpus ID: 205232231

Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells

@article{Araki2013NegligibleIO,
  title={Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells},
  author={R. Araki and M. Uda and Y. Hoki and Misato Sunayama and Miki Nakamura and S. Ando and M. Sugiura and H. Ideno and A. Shimada and A. Nifuji and M. Abe},
  journal={Nature},
  year={2013},
  volume={494},
  pages={100-104}
}

• R. Araki, M. Uda, +8 authors M. Abe
• Published 2013
• Biology, Medicine
• Nature

The advantages of using induced pluripotent stem cells (iPSCs) instead of embryonic stem (ES) cells in regenerative medicine centre around circumventing concerns about the ethics of using ES cells and the likelihood of immune rejection of ES-cell-derived tissues. However, partial reprogramming and genetic instabilities in iPSCs could elicit immune responses in transplant recipients even when iPSC-derived differentiated cells are transplanted. iPSCs are first differentiated into specific types… Expand