Negatively regulating TLR4/NF-κB signaling via PPARα in endotoxin-induced uveitis.

  title={Negatively regulating TLR4/NF-κB signaling via PPARα in endotoxin-induced uveitis.},
  author={Wei Shen and Yang Gao and Boyu Lu and Qingjiong Zhang and Yang Hu and Yin Chen},
  journal={Biochimica et biophysica acta},
  volume={1842 7},
Toll-like receptor (TLR) signaling plays a fundamental role in the induction and progression of autoimmune disease. In the present study, we showed that lipopolysaccharide (LPS), a TLR4 ligand, functions as an antagonist of peroxisome proliferator-activated receptor alpha (PPARα), a nuclear transcription factor. Using endotoxin induced uveitis (EIU) as a model, we found that TLR was negatively regulated by PPARα. Our data revealed that treatment with the PPARα agonist fenofibrate dramatically… CONTINUE READING
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