Negatively charged liposomes show potent adjuvant activity when simply admixed with protein antigens.

@article{Yanasarn2011NegativelyCL,
  title={Negatively charged liposomes show potent adjuvant activity when simply admixed with protein antigens.},
  author={Nijaporn Yanasarn and Brian R. Sloat and Zhengrong Cui},
  journal={Molecular pharmaceutics},
  year={2011},
  volume={8 4},
  pages={
          1174-85
        }
}
Liposomes have been investigated extensively as a vaccine delivery system. Herein the adjuvant activities of liposomes with different net surface charges (neutral, positive, or negative) were evaluated when admixed with protein antigens, ovalbumin (OVA, pI = 4.7), Bacillus anthracis protective antigen protein (PA, pI = 5.6), or cationized OVA (cOVA). Mice immunized subcutaneously with OVA admixed with different liposomes generated different antibody responses. Interestingly, OVA admixed with… CONTINUE READING
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