Negative symptoms of schizophrenia: new developments and unanswered research questions.

  title={Negative symptoms of schizophrenia: new developments and unanswered research questions.},
  author={Silvana Galderisi and Armida Mucci and Robert Williams Buchanan and Celso Arango},
  journal={The lancet. Psychiatry},
  volume={5 8},

Updated perspectives on the clinical significance of negative symptoms in patients with schizophrenia

The conceptualization, assessment, and treatment of this complex psychopathological dimension of schizophrenia is provided, and the development of state-of-the-art assessment instruments made in the last decades are provided.

Negative Symptoms in Schizophrenia: A Review and Clinical Guide for Recognition, Assessment, and Treatment

The objective of this review was to provide information that may be useful for clinicians treating patients with negative symptoms of schizophrenia, which constitute an unmet medical need in schizophrenia and new and effective treatments are urgently needed.

Primary and Secondary Negative Symptoms in Schizophrenia

This review and position paper covers the historical and modern concepts of the paradigm of positive and negative symptoms in schizophrenia, as well as a detailed comparison of the assessment tools and psychometric tests used for the evaluation of negative symptoms.

Negative symptoms in schizophrenia: clinical aspects and assessment

  • A. MuninI. Belokrylov
  • Medicine, Psychology
    Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery)
  • 2021
This article is a systematic analysis of the scientific medical literature regarding negative symptoms in schizophrenia, and it is now accepted that negative symptoms represent a two-factor model of impairment or absence of functions associated with motivation and verbal / emotional expression.

EPA guidance on treatment of negative symptoms in schizophrenia

Recommendations for the treatment of undifferentiated negative symptoms (including both primary and secondary negative symptoms) are provided and although it has proven difficult to formulate an evidence-based recommendation for the choice of an antipsychotic, a switch to a second-generation antipsychotics should be considered.

EPA guidance on assessment of negative symptoms in schizophrenia

This European Psychiatric Association (EPA) guidance recommends the use of persistent negative symptoms (PNS) construct in the context of clinical trials and highlights the need for further efforts to make the definition of PNS consistent across studies in order to exclude as much as possible secondary negative symptoms.

Avolition as the core negative symptom in schizophrenia: relevance to pharmacological treatment development

Network analytic findings indicate that avolition is highly central and interconnected with the other negative symptom domains in schizophrenia, and successfully remediating avolition results in global improvement in the entire constellation of negative symptoms.



Persistent negative symptoms in schizophrenia: an overview.

  • R. Buchanan
  • Psychology, Medicine
    Schizophrenia bulletin
  • 2007
The presence of persistent negative symptoms identifies a patient population with clinically relevant symptomatology, which is larger than the one with the deficit syndrome but less heterogeneous than that captured through the use of a nonrestrictive definition of negative symptoms.

The NIMH-MATRICS consensus statement on negative symptoms.

A consensus development conference was held to review the data relating to the existence of separate domains within negative symptoms, as a prerequisite for choosing appropriate measures of these domains in clinical trials and to examine issues that may interfere with treatment development.