Negative symptoms of psychosis: A life course approach and implications for prevention and treatment

  title={Negative symptoms of psychosis: A life course approach and implications for prevention and treatment},
  author={John Lyne and Brian O’Donoghue and Eric Roche and Laoise Renwick and Mary Cannon and Mary C. Clarke},
  journal={Early Intervention in Psychiatry},
  pages={561 - 571}
Negative symptoms are a cause of enduring disability in serious mental illness. In spite of this, the development of effective treatments for negative symptoms has remained slow. The challenge of improving negative symptom outcomes is compounded by our limited understanding of their aetiology and longitudinal development. 
Use of Bupropion in the Management of Negative Symptom Schizophrenia: A Case Series
A case series of three patients with a past psychiatric history of schizophrenia who presented to the psychiatric emergency with acute symptoms of schizophrenia are presented, and it is suggested that the anti-depressive effects of bupropion might be a valuable treatment option in the treatment of negative Symptoms of schizophrenia.
Negative Symptoms in Schizophrenia: A Review and Clinical Guide for Recognition, Assessment, and Treatment
The objective of this review was to provide information that may be useful for clinicians treating patients with negative symptoms of schizophrenia, which constitute an unmet medical need in schizophrenia and new and effective treatments are urgently needed.
Identifying clinical and psychological correlates of persistent negative symptoms in early-onset psychotic disorders.
PNS associated with blunted expression and low motivation/pleasure in the first episode could persist into clinical follow-up and effective pharmacological treatment and psychosocial interventions are needed in youth.
Prevalence, course and psychosis-predictive value of negative symptoms in 22q11.2 deletion syndrome
Negative symptoms in schizophrenia: clinical aspects and assessment
  • A. Munin, I. Belokrylov
  • Medicine, Psychology
    Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery)
  • 2021
This article is a systematic analysis of the scientific medical literature regarding negative symptoms in schizophrenia, and it is now accepted that negative symptoms represent a two-factor model of impairment or absence of functions associated with motivation and verbal / emotional expression.
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At 10 years, apathy was statistically significantly associated with reduced functioning, suggesting the early phase of the disorder may be critical to the development of apathy in FEP.
Associations of psychotic-like experiences, related symptoms, and working memory with functioning
Findings from this study suggest that symptom dimensions and working memory impairment were associated with diminished functioning across a variety of domains, and even in a non-clinical sample, sub-threshold psychosis symptoms and cognition may influence people’s social and role functioning.


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Treatment of negative symptoms of schizophrenia -- eg, problems with motivation, social withdrawal, diminished affective responsiveness, speech, and movement -- is associated with a variety of
Duration of active psychosis and first‐episode psychosis negative symptoms
Duration of untreated psychosis (DUP) has been associated with negative symptoms in several studies; however, longitudinal findings have been inconsistent. No previous study has accounted for active
Premorbid adjustment, symptom development and quality of life in first episode psychosis: a systematic review and critical reappraisal
Objective:  To systematically review the relationship of premorbid adjustment to symptomatology in first episode psychosis (FEP), taking into account the influence of duration of untreated psychosis
Negative symptoms of schizophrenia: a problem that will not go away
There are nevertheless neurobiological correlates of the negative symptom typology of the psychosis of schizophrenia.
Negative symptoms in schizophrenia: comments from a clinical psychology perspective.
The NIMH-MATRICS Consensus Statement on Negative Symptoms is covered from the perspective of Clinical Psychology and aspects of the Statement relating to psychological treatments are discussed.
Untreated illness and outcome of psychosis
This study extends the findings of short-term follow-up studies by confirming an association between duration of untreated psychosis and ‘midterm’ outcome.
Is active psychosis neurotoxic?
The clinical and neurobiological evidence for the validity of the hypothesis that synaptic plasticity, not neurotoxicity, appears to be the mediating process in early schizophrenia is visited and found wanting.
Prevalence and longitudinal stability of negative symptoms in healthy participants
The objective of this study was to evaluate whether negative symptoms are present in healthy populations and to determine whether they are linked to illness‐related processes or normal aging.
Psychopathological long‐term outcome of schizophrenia – a review
Focussing on the psychopathological long‐term outcome, the present article aims to review follow‐up studies that used modern operationalized diagnostic criteria for schizophrenia (DSM‐III, DSM‐III‐R, DSM-IV and ICD‐10) in the past.
Enduring negative symptoms in first-episode psychosis: comparison of six methods using follow-up data