Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter.

@article{Sandel1999NegativeSO,
  title={Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter.},
  author={Peter C. Sandel and John Monroe},
  journal={Immunity},
  year={1999},
  volume={10 3},
  pages={289-99}
}
Immature B cells that encounter self-antigen are eliminated from the immune repertoire by negative selection. Negative selection has been proposed to take place by two distinct mechanisms: deletion by apoptosis or alteration of the antigen receptor specificity by receptor editing. While convincing evidence exists for each, the two models are inherently contradictory. In this paper, we propose a resolution to this contradiction by demonstrating that the site of first antigen encounter dictates… CONTINUE READING

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