Negative role of inducible PD-1 on survival of activated dendritic cells.

  title={Negative role of inducible PD-1 on survival of activated dendritic cells.},
  author={Seong Jeong Park and Hong Namkoong and Junsang Doh and Jong-Cheol Choi and Bo-gie Yang and Yunji Park and Young Chul Sung},
  journal={Journal of leukocyte biology},
  volume={95 4},
PD-1 is a well-established negative regulator of T cell responses by inhibiting proliferation and cytokine production of T cells via interaction with its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2), expressed on non-T cells. Recently, PD-1 was found to be expressed in innate cells, including activated DCs, and plays roles in suppressing production of inflammatory cytokines. In this study, we demonstrate that PD-1 KO DCs exhibited prolonged longevity compared with WT DCs in the dLNs after transfer… CONTINUE READING
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