Negative relationship between morphine analgesia and P-glycoprotein expression levels in the brain.

@article{Hamabe2007NegativeRB,
  title={Negative relationship between morphine analgesia and P-glycoprotein expression levels in the brain.},
  author={Wakako Hamabe and Takehiko Maeda and Norikazu Kiguchi and Chizuko Yamamoto and Shogo Tokuyama and Shiroh Kishioka},
  journal={Journal of pharmacological sciences},
  year={2007},
  volume={105 4},
  pages={353-60}
}
It is known that opioid analgesics given systemically have limited distribution into the brain because of their interaction with P-glycoprotein (P-gp), an ATP-dependent efflux pump acting at the blood-brain barrier (BBB). We previously found that morphine and fentanyl showed higher analgesic potencies in P-gp-deficient mice compared with those in wild-type mice, suggesting that their analgesic effects are considerably dependent on P-gp expression. In this study, we focused on individual… CONTINUE READING

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