Negative regulators of cytokine signal transduction

  title={Negative regulators of cytokine signal transduction},
  author={Douglas J. Hilton},
  journal={Cellular and Molecular Life Sciences CMLS},
Enormous advances have been made over the last 10 years in unravelling cytokine signal transduction. This work has led to the recognition of the prime importance of Janus kinases (JAKs) and signal transducers and activators of transcription (STATs). More recently, the importance of negative regulators of this pathway has begun to be realised. There is now evidence for at least three families of proteins that inhibit JAK/STAT signalling. The supressors of cytokine signalling (SOCS), protein… CONTINUE READING
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