Negative regulators of cell death pathways in cancer: perspective on biomarkers and targeted therapies

@article{Razaghi2018NegativeRO,
  title={Negative regulators of cell death pathways in cancer: perspective on biomarkers and targeted therapies},
  author={Ali Razaghi and K. Heimann and P. Schaeffer and S. Gibson},
  journal={Apoptosis},
  year={2018},
  volume={23},
  pages={93-112}
}
Cancer is a primary cause of human fatality and conventional cancer therapies, e.g., chemotherapy, are often associated with adverse side-effects, tumor drug-resistance, and recurrence. Molecularly targeted therapy, composed of small-molecule inhibitors and immunotherapy (e.g., monoclonal antibody and cancer vaccines), is a less harmful alternative being more effective against cancer cells whilst preserving healthy tissues. Drug-resistance, however, caused by negative regulation of cell death… Expand
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