Negative regulation of the human epsilon-globin gene by transcriptional interference: role of an Alu repetitive element.

@article{Wu1990NegativeRO,
  title={Negative regulation of the human epsilon-globin gene by transcriptional interference: role of an Alu repetitive element.},
  author={June K. Wu and G. Joan Grindlay and P Bushel and Lawrence Mendelsohn and Martin Allan},
  journal={Molecular and cellular biology},
  year={1990},
  volume={10 3},
  pages={1209-16}
}
The human epsilon-globin gene has a number of alternative transcription initiation sites which correspond with regions of DNase I hypersensitivity upstream of the canonical cap site. Transcripts originating from the promoters located -4.3/-4.5 and -1.48 kilobase pairs (kbp) and -900 and -200 base pairs (bp) upstream of the major epsilon-globin cap site can, at certain stages of erythroid differentiation, extend through the gene and are polyadenylated. The 350-bp PolIII transcripts, originating… CONTINUE READING

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